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BREAKING: Scientists Produced A Chewing Gum That Reduces C-19 Transmission!

The latest study from the University of Pennsylvania adds a tool to the utility belt of C-19 treatments.

This innovation serves as a breath freshener and C-19 viral load suppresser.

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Scientists from the University of Pennsylvania used saliva samples of C-19 patients to examine the chewing gum laced with a plant-grown protein. It traps the virus to reduce the viral load in saliva and stop the transmission.

The researchers said that the gum has the ACE2 protein that neutralizes the virus.

EurekAlert reported:

The work, led by Henry Daniell at Penn’s School of Dental Medicine and performed in collaboration with scientists at the Perelman School of Medicine and School of Veterinary Medicine, as well as at The Wistar Institute and Fraunhofer USA, could lead to a low-cost tool in the arsenal against the COVID-19 pandemic. Their study was published in the journal Molecular Therapy.

“SARS-CoV-2 replicates in the salivary glands, and we know that when someone who is infected sneezes, coughs, or speaks some of that virus can be expelled and reach others,” says Daniell. “This gum offers an opportunity to neutralize the virus in the saliva, giving us a simple way to possibly cut down on a source of disease transmission.”

Because the vaccines don’t stop the transmission, Daniell’s work gives an innovative solution to reduce the viral load!

EurtkAlert described the process of testing the chewing gum:

To test the chewing gum, the team grew ACE2 in plants, paired with another compound that enables the protein to cross mucosal barriers and facilitates binding, and incorporated the resulting plant material into cinnamon-flavored gum tablets. Incubating samples obtained from nasopharyngeal swabs from COVID-positive patients with the gum, they showed that the ACE2 present could neutralize SARS-CoV-2 viruses.

Those initial investigations were followed by others at The Wistar Institute and Penn Vet, in which viruses, less-pathogenic than SARS-CoV-2, were modified to express the SARS-CoV-2 spike protein. The scientists observed that the gum largely prevented the viruses or viral particles from entering cells, either by blocking the ACE2 receptor on the cells or by binding directly to the spike protein.

Finally, the team exposed saliva samples from COVID-19 patients to the ACE2 gum and found that levels of viral RNA fell so dramatically to be almost undetectable.

The researchers said it was effective and asked for permission to perform a clinical trial with C-19 positive patients.

The research is in its primary stages, but the trials show that the gum is safe and effective. This could be a game-changer.

Below you can read an excerpt from ‘‘Debulking SARS-CoV-2 in saliva using angiotensin-converting enzyme 2 in chewing gum to decrease oral virus transmission and infection.

To advance a novel concept of debulking virus in the oral cavity, the primary site of viral replication, virus-trapping proteins CTB-ACE2 were expressed in chloroplasts and clinical-grade plant material was developed to meet FDA requirements. Chewing gum (2 g) containing plant cells expressed CTB-ACE2 up to 17.2 mg ACE2/g dry weight (11.7% leaf protein), have physical characteristics and taste/flavor like conventional gums, and no protein was lost during gum compression. CTB-ACE2 gum efficiently (>95%) inhibited entry of lentivirus spike or VSV-spike pseudovirus into Vero/CHO cells when quantified by luciferase or red fluorescence. Incubation of CTB-ACE2 microparticles reduced SARS-CoV-2 virus count in COVID-19 swab/saliva samples by >95% when evaluated by microbubbles (femtomolar concentration) or qPCR, demonstrating both virus trapping and blocking of cellular entry. COVID-19 saliva samples showed low or undetectable ACE2 activity when compared with healthy individuals (2,582 versus 50,126 ΔRFU; 27 versus 225 enzyme units), confirming greater susceptibility of infected patients for viral entry. CTB-ACE2 activity was completely inhibited by pre-incubation with SARS-CoV-2 receptor-binding domain, offering an explanation for reduced saliva ACE2 activity among COVID-19 patients. Chewing gum with virus-trapping proteins offers a general affordable strategy to protect patients from most oral virus re-infections through debulking or minimizing transmission to others.

And this is from the discussion:

The oral cavity is an important portal of entry for SARS-CoV-2 virus and plays a particularly significant role in the transmission of infection or continued re-infection. The heterogeneity of the oral mucosa at a cellular level and presence of several ubiquitous receptors including ACE2 and GM1 facilitate entry of oral pathogens. Saliva plays a vital role in transmission of infection among critically ill patients and can also compromise oral tissues. Reducing the viral load in saliva should limit the risk of transmission from a potential carrier and may help reduce the severity of COVID-19 disease by minimizing re-infection because salivary glands constitute the primary site of SARS-CoV-2 replication. Therefore, we explore the ability of CTB-ACE2 chewing gum to trap SARS-CoV-2 to debulk virus from saliva in pre-clinical studies that provide a foundation of clinical testing designed to reduce oral viral load and transmission.

Source
Eurekalert twitter

Addison Wilson

A passionate teacher in English Language and Literature ready to give her best! Developing and implementing diverse curriculums covering a wide range of subjects. With my problem-solving skills, every job will be easily completed, so punctuation is my strength. Highly skilled at motivating students through positive encouragement and reinforcement of concepts via interactive classroom instruction and observation. My working style fits every personality type, so it makes me a great team player. I have completed numerous journalistic projects successfully, so digging for further information is my field. Fighter for freedom of speech! The truth must be revealed!

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